Steri-lysis™ is a novel non-thermal plasma (NTP) technology that generates a highly active reactive oxygen and nitrogen species mixture within a closed loop system. We are investigating the effectiveness of NTP for the treatment of infected wounds and early results are promising for clinical translation.
We are investigating the use of DHA to create a rapidly degradable implantable device to facilitate safe fascial closure for abdominal surgery.
CLEFT LIP / CLEFT PALATE
We designed a minimally invasive surgical approach suitable for intrauterine repair of CL/P using Wnt9b-soaked Type I collagen microspheres to restore craniofacial development for cleft correction.
This project demonstrated, for the first time, lipid transfer directly from a fat cell into a breast cancer cell.
ANTIGEN MEDIATED WOUND HEALING
Macrophages are key mediators of the immune response and of wound healing. We have demonstrated that wound healing is accelerated by a one-time application of alpha-gal containing nanoparticles through its stimulation of a strong macrophage response.
This project aims to utilize the proangiogenic potential of intermittent hypoxia on endothelial cells to induce sprouting and capillary bed formation in tissue engineered constructs for dermal replacement.
We are investigating the use of novel anti-inflammatory molecules as a method of reducing capsular contracture, one of the major complications of breast reconstruction.